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Nexium increases blood levels of diazepam (Valium) by decreasing the elimination of diazepam in the liver. Nexium and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). Co-administration of Nexium with Clarithromycin increaes area under the plasma concentration time curve (AUC) of the first. Nexium may slow down metabolism of such medications: citalopram, diazepam, clomipramine, phenytoin, imipramine. Consequently their dose should be corrected.
Together with signs of allergy like hives, swelling of throat and face, rash patients may experience headache, diarrhea, nausea, abdominal pain, flatulence (gas), constipation, or dry mouth. Notify your doctor if you think that you took too much of this medication.
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