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Why myasthenia gravis worsens with activity? Normally, the amount of acetylcholine available to be released to muscle cells diminishes with repeated, prolonged or strenuous activity. In a person with myasthenia gravis, that normal decrease combined with fewer working receptors causes increasing weakness, or myasthenic fatigue.
Does ocular myasthenia gravis cause fatigue? Myasthenia gravis is a relatively rare neuromuscular disease in which the voluntary muscles easily become tired and weak because there is a problem with how the nerves stimulate the contraction of muscles. It is an autoimmune disorder. The muscles around the eyes tend to be affected first, causing the eyelids to droop.
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